Saphnelo (anifrolumab-fnia) is a prescription medicine that is used to treat systemic lupus erythematosus (SLE) in adult patients. It is a monoclonal antibody that works by binding to type I interferon receptors and inhibiting type I interferon signaling, a key driver of SLE. In this article, we will discuss Saphnelo’s prescribing information, including dosage, side effects, and precautions.
Dosage
The recommended dosage of Saphnelo is 300 mg administered intravenously (IV) every four weeks. It is recommended that Saphnelo be administered by a healthcare professional in a setting equipped to manage anaphylaxis in case of a severe allergic reaction. Saphnelo should be diluted in 0.9% sodium chloride injection to a concentration of 3 mg/mL prior to IV infusion.
Side Effects
The most common side effects observed with Saphnelo treatment are nausea, fatigue, injection site reactions, and fever. Other potential side effects include respiratory tract infections, urinary tract infections, and herpes zoster infections. Saphnelo may also increase the risk of developing serious infections, such as pneumonia or sepsis. It is important to discuss any potential side effects with your healthcare provider.
Precautions
Before starting Saphnelo treatment, it is important to inform your healthcare provider about any allergies, medical conditions, and medications you are currently taking. Saphnelo should not be administered to patients with a known history of severe allergic reactions to any component of the product. Patients undergoing Saphnelo treatment should be closely monitored for signs of infection and advised to seek medical attention promptly if any symptoms develop.
In conclusion, Saphnelo is a prescription medication used to treat SLE in adult patients. The recommended dosage is 300 mg administered IV every four weeks. The most common side effects include nausea, fatigue, injection site reactions, and fever. Patients should be closely monitored for signs of infection and advised to seek medical attention promptly if any symptoms develop. It is important to discuss any potential risks and benefits with your healthcare provider and adhere to their instructions for Saphnelo treatment.
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