Everything You Need to Know About Fabrazyme Prescribing Information

Fabrazyme (agalsidase beta) is a prescription medication used for the treatment of Fabry disease. Fabry disease is a genetic disorder that affects the body’s ability to break down a type of fat called globotriaosylceramide (GL-3). Over time, this buildup can damage the kidneys, heart, and nervous system.

In this article, we’ll take a closer look at Fabrazyme prescribing information, including its uses, dosage, administration, and potential side effects.

Uses

Fabrazyme is used to treat Fabry disease in both adults and children. It works by replacing the missing enzyme (alpha-galactosidase A) in the body that is needed to break down GL-3. This helps to reduce the buildup of GL-3 in the body and prevent further damage to the kidneys, heart, and nervous system.

Dosage

Fabrazyme is administered intravenously (injected into a vein). The dosage and frequency of administration depends on the patient’s weight and kidney function. The recommended starting dose is 0.2 mg/kg of body weight administered every other week. The dosage may be adjusted based on the patient’s response to treatment and individual circumstances.

Administration

Fabrazyme should only be administered by a healthcare professional in a medical setting. The medication is supplied as a lyophilized powder that must be reconstituted with sterile water before administration. The reconstituted solution should be clear and colorless. Any solution that is discolored or contains particles should not be used.

The medication should be administered over a period of at least 40 minutes. Patients should be monitored for any adverse reactions during and after administration.

Side Effects

Like all medications, Fabrazyme can cause side effects. The most common side effects include:

– Infusion-related reactions (fever, chills, headache, flushing, nausea, vomiting, rash, itching, difficulty breathing)
– Fatigue
– Pain (back, joint, muscle)
– Nausea
– Headache
– Fever

Most infusion-related reactions occur within the first few hours of treatment and can be managed with antihistamines, corticosteroids, or other supportive measures. Patients should be closely monitored for any signs of a reaction and treatment should be stopped if necessary.

In rare cases, Fabrazyme can cause severe allergic reactions that can be life-threatening. Patients should seek medical attention immediately if they experience any signs of an allergic reaction, including:

– Difficulty breathing
– Swelling of the face, tongue, or throat
– Hives

Conclusion

Fabrazyme is an important medication for the treatment of Fabry disease. It works by replacing the missing enzyme needed to break down GL-3 in the body and prevent further damage to vital organs. However, it is important to follow the prescribed dosage and administration guidelines to reduce the risk of adverse reactions. Patients should also be closely monitored for any signs of a reaction and seek medical attention if necessary.

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