Introduction
Abraxane is a medication used to treat breast cancer, pancreatic cancer, and non-small cell lung cancer. Understanding the prescribing information for Abraxane is critical for healthcare professionals who prescribe this medication. In this comprehensive guide, we will explore the prescribing information for Abraxane in detail, providing readers with a better understanding of how to use this medication safely and effectively.
What Is Abraxane?
Abraxane is the trade name for paclitaxel protein-bound particles for injectable suspension. It is a chemotherapy medication that works by interfering with the growth and spread of cancer cells. Abraxane is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within six months of adjuvant chemotherapy. It is also indicated for the treatment of metastatic pancreatic cancer and non-small cell lung cancer.
Dosing and Administration
Abraxane is administered by intravenous infusion over 30 minutes. The recommended dose of Abraxane for metastatic breast cancer is 260 mg/m2 administered over 30 minutes every three weeks. The recommended dose for pancreatic cancer is 125 mg/m2 administered over 30 minutes once per week for three weeks followed by one week off. The recommended dose for non-small cell lung cancer is 100 mg/m2 administered over 30 minutes on days 1, 8, and 15 of each 21-day cycle.
Special Populations
Special populations, including patients with hepatic impairment, renal impairment, or elderly patients, may require dosage adjustments. For patients with hepatic impairment, the dose of Abraxane should be reduced by 50%. For patients with severe renal impairment, the dose of Abraxane should be reduced by 20%. For elderly patients, no dose adjustments are required.
Warnings and Precautions
Abraxane can cause severe hypersensitivity reactions. Patients should be monitored closely for signs of hypersensitivity, including flushing, shortness of breath, chest pain, or swelling of the face. Patients who experience severe hypersensitivity reactions should immediately stop taking Abraxane and receive appropriate treatment.
Conclusion
In summary, Abraxane is a medication used to treat breast cancer, pancreatic cancer, and non-small cell lung cancer. Healthcare professionals who prescribe this medication must understand the dosing and administration, special populations, and warnings and precautions associated with Abraxane. By following the prescribing information for Abraxane, healthcare professionals can use this medication safely and effectively to help their patients combat cancer.
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