Gout is a debilitating condition that causes excruciating pain, swelling, and redness in the joints, especially in the big toe. The condition is caused by the buildup of uric acid crystals in the joints due to high levels of uric acid in the blood. Until recently, gout treatment mostly involved pain relievers, anti-inflammatory drugs, lifestyle changes, and dietary modifications. However, with the introduction of revolutionary new medications, treating gout has become more manageable and efficient. In this article, we explore what you need to know about these new medications.
1. Febuxostat (Uloric)
Febuxostat is a pharmaceutical drug that works by lowering uric acid levels, hence reducing the number of gout attacks. The medication is taken orally once per day, with or without food. Unlike its predecessor, allopurinol, febuxostat does not require dosage adjustments for patients with kidney problems. Clinical trials have shown that febuxostat is relatively safe and effective in managing gout.
2. Pegloticase (Krystexxa)
Pegloticase was approved by the FDA in 2010 for gout treatment. This medication works by breaking down uric acid into a harmless compound that can be eliminated from the body. Pegloticase is administered intravenously by a healthcare provider, usually once every two weeks. It is recommended for patients who have not responded well to other gout medications. Studies have shown that pegloticase can significantly reduce uric acid levels and gout symptoms.
3. Lesinurad (Zurampic)
Lesinurad is a medication that helps the kidneys eliminate uric acid from the body. It is usually taken in combination with other gout medications, such as allopurinol or febuxostat. The drug is taken orally once per day, with or without food. Lesinurad is recommended for patients who have not responded well to other gout medications. Clinical trials have shown that lesinurad is relatively safe and effective in managing gout.
4. Colchicine (Colcrys)
Colchicine is a medication that works by reducing inflammation in the joints that causes gout pain. The medication is taken orally, usually in tablet form. Colchicine is recommended for the treatment of acute gout attacks and the prevention of recurrent gout attacks. It is usually prescribed in low doses to minimize side effects.
Conclusion
In conclusion, the introduction of new medications has given hope to millions of people suffering from gout worldwide. It is essential to work with a healthcare provider to determine the best course of treatment for your gout condition. Depending on the severity of the condition, the healthcare provider may recommend one or a combination of these medications. Additionally, it is crucial to maintain a healthy lifestyle and adhere to dietary modifications to help manage gout symptoms and prevent future attacks.
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